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Beta-2 Glycoprotein 1 Antibodies, IgG and IgM, Serum

Additional Codes

Orderable Codes:

Epic Code Atlas Code Mayo Test ID Order LOINC
LAB2335 B2GP B2GMG 72488-0

Result Component(s):

Reporting Name Epic Code Atlas Code Mayo Test ID Result LOINC
Beta 2 GP1 Ab IgG 12301000606 GB2GP GB2GP 44448-9
Beta 2 GP1 Ab IgM 12301000607 MB2GP MB2GP 44449-7

 

Useful For

Evaluating patients with suspected antiphospholipid syndrome by identification of beta-2 glycoprotein 1 IgM and IgG antibodies

 

First-line test when antiphospholipid syndrome is strongly suspected in conjunction with cardiolipin antibodies (IgG and IgM) and lupus anticoagulant testing

 

Estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus

Profile Information

Test ID Reporting Name Available Separately Always Performed
GB2GP Beta 2 GP1 Ab IgG, S Yes Yes
MB2GP Beta 2 GP1 Ab IgM, S Yes Yes

Reporting Name

Beta 2 GP1 Ab, IgM/IgG, S

Specimen Type

Serum


Additional Testing Requirements


Diagnostic criteria for antiphospholipid syndrome include the presence of at least one of the following: lupus anticoagulant, anticardiolipin, and anti-beta-2 glycoprotein 1 IgG or IgM antibodies. Consider ordering CLPMG / Phospholipid (Cardiolipin) Antibodies, IgG and IgM, Serum and ALUPP / Lupus Anticoagulant Profile, Plasma concurrently with this test.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK
Heat-treated specimens Reject

Reference Values

BETA 2 GLYCOPROTEIN 1 (GP1) ANTIBODIES IgG:

<15.0 SGU (negative)

15.0-39.9 SGU (weakly positive)

40.0-79.9 SGU (positive)

≥ 80.0 SGU (strongly positive)

Results are reported in standard IgG anti-beta 2 GP1 units (SGU).

 

Reference values apply to all ages.

 

BETA 2 GLYCOPROTEIN 1 ANTIBODIES IgM:

<15.0 SMU (negative)

15.0-39.9 SMU (weakly positive)

40.0-79.9 SMU (positive)

≥ 80.0 SMU (strongly positive)

Results are reported in standard IgM anti-beta 2 GP1 units (SMU).

 

Reference values apply to all ages.

Day(s) Performed

Monday through Saturday

Report Available

2 to 6 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86146 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
B2GMG Beta 2 GP1 Ab, IgM/IgG, S 72488-0

 

Result ID Test Result Name Result LOINC Value
GB2GP Beta 2 GP1 Ab IgG, S 44448-9
MB2GP Beta 2 GP1 Ab IgM, S 44449-7

NY State Approved

Yes

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Coagulation Test Request (T753)

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.