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Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma

Important Note

This test must be collected at the Main Campus, 111 Colchester Avenue, Burlington, VT.

BOTH Plasma and Serum are Required.

Additional Codes

Orderable Codes:

Epic Code Atlas Code Mayo Test ID Order LOINC
LAB17886 LAB17886 CRGSP 74352-6

Result Component(s):

Reporting Name Epic Code Atlas Code Mayo Test ID Result LOINC
Cryoglobulin, S. 12301006080 MCRYS 2684 12201-0
Cryofibrinogen, P. 12301021348 M2685 2685 11043-7

 

Reporting Name

Cryo Panel, S and P

Useful For

Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases

 

Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

 

This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRY_S Cryoglobulin, S Yes Yes
CRY_P Cryofibrinogen, P No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFXC Immunofixation Cryoglobulin No No

Testing Algorithm

If cryoglobulin has a positive result after 1 or 7 days, then immunofixation will be performed at an additional charge. Immunofixation will only be performed once when positive cryoglobulin results are 0.1 mL of precipitate or greater.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma EDTA
Serum Red


Specimen Required


Both plasma and serum are required.

Patient Preparation: Fasting: 12 hours, preferred but not required

 

Specimen Type: Plasma

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL Plasma

Collection Instructions:

1. Tube must remain at 37° C.

2. Centrifuge at 37° C. Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable. It is very important that the specimen remains at 37° C until after separation of plasma from red blood cells.

3. Place plasma into an appropriately labeled plastic vial.

 

Specimen Type: Serum

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 5 mL Serum

Collection Instructions:

1. Tube must remain at 37° C.

2. Allow blood to clot at 37° C.

3. Centrifuge at 37° C. Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable. It is very important that the specimen remains at 37° C until after separation of serum from red blood cells.

4. Place serum into an appropriately labeled plastic vial.

Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require collection and submission of a new specimen.


Specimen Minimum Volume

Plasma: 0.5 mL; Serum: 3 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Refrigerated (preferred)
  Frozen 
Serum Red Refrigerated (preferred)
  Frozen 

Reference Values

CRYOGLOBULIN

Negative

Positive results are reported as a percentage or trace amount.

 

CRYOFIBRINOGEN

Negative

Day(s) Performed

Monday through Friday

CPT Code Information

82585

82595

86334-Immunofixation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRGSP Cryo Panel, S and P 74352-6

 

Result ID Test Result Name Result LOINC Value
2685 Cryofibrinogen, P 11043-7
2684 Cryoglobulin, S 12201-0

Report Available

2 to 10 days

Specimen Retention Time

Serum: Negative: 7 days post receipt; Positive: Until reported up to 10 days; Plasma: Not retained

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

NY State Approved

Yes

Method Name

CRY_S, CRY_P: Quantitation and Qualitative Typing Precipitation

IMFXC: Immunofixation

Forms

If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.