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HelpCryoglobulin, Serum
Additional Codes
| Epic Code | Atlas Code | Mayo Test ID | Order LOINC |
| LAB713 | CRYOGS | CRY_S | 12201-0 |
Reporting Name
Cryoglobulin, SUseful For
Evaluating cryoglobulins in patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases
Evaluating cryoglobulins in patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure
This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IMFXC | Immunofixation Cryoglobulin | No | No |
Testing Algorithm
If cryoglobulin has a positive result after 1 or 7 days, then immunofixation will be performed at an additional charge. Positive cryoglobulins of 0.1 mL or above of precipitate will be typed once.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum Red***Samples must be clotted at 37 degrees C. ***
Draw blood in a syringe or vacutainer that has been prewarmed to body temperature. After drawing the sample, place in cup of 37 degree water. Sample should be placed in a controlled 37 degree waterbath for one hour.
Special Instructions for Test CRYOGS: SAMPLE MUST STAY AT 37C. Draw blood in a syringe or vacutainer that has been prewarmed to body temperature. After drawing the sample, place in cup of 37 degree water. DRAW 2 FULL RED TOP Tubes.
Ordering Guidance
This test is also available as a part of a profile to assess for both cryofibrinogen and cryoglobulin. For more information see CRGSP / Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma.
Specimen Required
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions:
1. Tube must remain at 37° C.
2. Allow blood to clot at 37° C.
3. Centrifuge at 37° C. Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable. It is very important that the specimen remain at 37° C until after separation of serum from red blood cells.
4. Place serum into an appropriately labeled plastic vial.
Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require collection and submission a new specimen.
Specimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | ||
| Frozen | |||
Reference Values
Negative (positives reported as percent or trace amount)
If positive after 1 or 7 days, immunotyping of the cryoprecipitate is performed at an additional charge.
Day(s) Performed
Monday through Friday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82595
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CRY_S | Cryoglobulin, S | 12201-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 2684 | Cryoglobulin, S | 12201-0 |
Report Available
2 to 10 daysSpecimen Retention Time
2 weeksReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
NY State Approved
YesMethod Name
CRY_S: Quantitation and Qualitative Typing Precipitation
IMFXC: Immunofixation
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.