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Test Code LAB2736 CELIAC DISEASE PANEL

Important Note

Testing includes Tissue Transglutaminase Antibody IgA and IgA .

Additional Codes

Orderable Codes:

Epic Code Atlas Code Mayo Access ID Order LOINC Legacy Code
LAB2736 LAB2736 FAH6169 94494-2 CDP

Result Component(s):

Reporting Name Epic Code Atlas Code Mayo Access ID Result LOINC
Tissue Transglutaminase Ab, IgA 12301020069 12301020069 FAH6132 46128-5
IgA 12301002021 IGAS FAH5813 2458-8
Celiac Disease Interpretation 12301000618 CDSP1 FAH5798 69048-7

 

Specimen Information

Container Specimen Temperature Collect Vol Submit Vol Min Vol Stability
SST Serum Refrigerate 2 mL 1 mL 0.5 mL 48 hours
SST Serum Frozen 2 mL 1 mL 0.5 mL 1 month

Serum should be separated from the clot within 4 hours of collection.  Store samples at room temperature no longer than 8 hours.  If the assay will not be completed within 8 hours, refrigerate the sample at 2-8C.  If the assay will not be completed within 48 hours, or for shipment of the sample, freeze at -20C or lower. 

Test Schedule / Analytical Time / Test Priority

Monday - Friday / Same day / Not available STAT

Method

Immunofluorescence

Instrumentation

Werfen QUANTA-Lyser and NOVA View

Reference Range

If TTAB positive (>30 CU) and IgA normal:
"Celiac disease possible. Consider referral to gastroenterology specialist for consideration for biopsy."

If IgA is age-specific normal and TTAB is weak positive (20-30 CU): 
"Equivocal serology, celiac disease cannot be excluded. Referral to gastroenterology specialist recommended for additional evaluation.”
 

If IgA is age specific normal and TTAB is negative (<20 CU): 
"Negative Serology. Celiac disease unlikely. Approximately 10% of patient with celiac disease are seronegative. Patients who are already adhering to a gluten-free diet may be seronegative. If celiac disease is highly clinically suspected, referral to gastroenterology for additional evaluation is recommended.”
 

If IgA > 6.7 mg/dl, but lower than age-specific normal and TTAB is negative (<20 CU): “Low total serum IgA; Recommend referral to gastroenterology specialist for additional evaluation.”
 

If IgA is below detection (< 6.7 mg/dl) and TTAB is negative (<20 CU):
“Total serum IgA deficiency; Recommend referral to gastroenterology specialist for additional evaluation.”

Section

Immunology and Chemistry-2

Performing Location

University of Vermont Medical Center

Is the UVMMC lab NY State Certified to perform this testing?  Yes/No

Yes

CPT Code(s)

82784, 86364