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HelpAlpha-Fetoprotein (AFP), Single Marker Screen, Maternal, Serum
Additional Codes
| Primary ID | Epic Code | Mayo Test ID |
| AFPSM1 | LAB692 | MAFP1 |
Necessary Information
In order to provide the best results, either answer the order entry questions or provide the required information using the Second Trimester Maternal Screening Alpha-Fetoprotein / Quad Screen Patient Information (T595).
Specimen Required
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Do not collect specimen after amniocentesis as this could affect results.
2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Additional Information:
1. Collect blood between 15 weeks, 0 days and 22 weeks, 6 days.
2. Initial or repeat testing is determined in the laboratory at the time of report and will be reported accordingly. To be considered a repeat test for the patient, the testing must be within the same pregnancy and trimester, with interpretable results for the same test, and both tests are performed at Mayo Clinic.
Forms
1. Second Trimester Maternal Screening Alpha-Fetoprotein / Quad Screen Patient Information (T595) is required
2. If not ordering electronically, complete, print, and send a General Request (T239)
Useful For
Prenatal screening for open neural tube defect
Special Instructions
Method Name
Two-Site Immunoenzymatic (Sandwich) Assay
Reporting Name
AFP Single Marker SCRN, Maternal, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
NEURAL TUBE DEFECTS:
An alpha-fetoprotein (AFP) multiple of the median (MoM) <2.5 is reported as screen negative.
AFP MoM ≥2.5 (singleton and twin pregnancies) are reported as screen positive.
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Report Available
4 to 6 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82105
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MAFP1 | AFP Single Marker SCRN, Maternal, S | 48802-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 7058 | Recalculated Maternal Serum Screen | 32399-8 |
| 113146 | Results Summary | 32399-8 |
| 113147 | Neural tube defect risk estimate | 48803-1 |
| 10351 | AFP | 83073-7 |
| 113148 | AFP MoM | 23811-3 |
| 10356 | INTERPRETATION | 49092-0 |
| 10357 | RECOMMENDED FOLLOW UP | 80615-8 |
| 10248 | Additional comments | 48767-8 |
| 3009 | Specimen collection date | 33882-2 |
| 7823 | Maternal date of birth | 21112-8 |
| 7834 | Calculated age at EDD | 43993-5 |
| 26717 | Maternal Weight | 29463-7 |
| 26718 | Maternal Weight | 29463-7 |
| IDD | Insulin dependent diabetes | 44877-9 |
| RACE1 | Patient race | 21484-1 |
| SMKNG | Current cigarette smoking status | 64234-8 |
| 10054 | EDD by U/S scan | 11781-2 |
| 7203 | GA on collection by U/S scan | 11888-5 |
| 7753 | EDD by LMP | 11779-6 |
| 7204 | GA on collection by dates | 11885-1 |
| 7830 | GA used in risk estimate | 21299-3 |
| MULTF | Number of Fetuses | 55281-0 |
| CHOR_ | Number of Chorions | 92568-5 |
| IVFP | IVF pregnancy | 47224-1 |
| PRNTD | Prev Pregnancy w/ Neural Tube Defect | 53827-2 |
| PTNTD | Patient or father of baby has a NTD | 53827-2 |
| INTL | Initial or repeat testing | 77202-0 |
| DRPHN | Physician Phone Number | 68340-9 |
| 10358 | GENERAL TEST INFORMATION | 62364-5 |