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MPL Exon 10 Mutation Detection, Reflex, Varies

Important Note

Test subject to Local Coverage Determination (LCD) Molecular Pathology Procedures (L35000).

Please check with the patient’s insurance to determine if prior authorization is required. Reminder- Medicare does not provider prior authorization. If in doubt about the coverage for a Medicare patient, please obtain an ABN.

Additional Codes

Primary ID

 Epic Code

Mayo Test ID

MPL

Reflex order only

 MPLR

 

Reporting Name

MPL Exon 10 Mutation Detection, R

Specimen Type

Varies


Specimen Required


Only orderable as a reflex. For more information see MPNR / Myeloproliferative Neoplasm (MPN), JAK2 V617F with reflex to CALR and MPL.


Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Varies 7 days

Reference Values

Only orderable as a reflex. For more information see MPNR / Myeloproliferative Neoplasm, JAK2 V617F with Reflex to CALR and MPL, Varies.

 

An interpretive report will be provided.

Specimen Retention Time

Whole blood, bone marrow: 2 weeks; Extracted DNA: 3 months

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

81339-MPL (myeloproliferative leukemia virus oncogene, thrombopoietin receptor, TPOR) (eg, myeloproliferative disorder), exon 10 sequence

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MPLR MPL Exon 10 Mutation Detection, R 62948-5

 

Result ID Test Result Name Result LOINC Value
36672 Final Diagnosis 22637-3

NY State Approved

Yes

Method Name

Only orderable as a reflex. For more information see MPNR / Myeloproliferative Neoplasm, JAK2 V617F with Reflex to CALR and MPL, Varies.

 

Sanger Sequencing

Useful For

Aiding in the distinction between a reactive cytosis and a chronic myeloproliferative disorder

 

Evaluates for mutations in MPL in an algorithmic process for the MPNR / Myeloproliferative Neoplasm, JAK2 V617F with Reflex to CALR and MPL, Varies

Reject Due To

Gross hemolysis Reject
Paraffin embedded bone marrow aspirate clot or biopsy blocks
Slides
Paraffin shavings
Moderately to severely clotted		 Reject

Day(s) Performed

Monday through Friday

Report Available

7 to 10 days