Home
HelpLeukotriene E4, Random, Urine
Additional Codes
Orderable Codes:
| Epic Code | Atlas Code | Mayo Test ID | Order LOINC |
| LAB17701 | LAB17701 | RLTE4 | 33343-5 |
Result Component(s):
| Reporting Name | Epic Code | Atlas Code | Mayo Test ID | Result LOINC |
| Leukotriene E4, Random, U. | 12301020393 | M603457 | 603457 | 33343-5 |
| Creatinine, Random, U. | 12301020394 | MCRTFR | CRTFR | 2161-8 |
Ordering Guidance
Patients with mast cell activation syndrome may have chronically elevated leukotriene E4 (LTE4), however, in certain situations LTE4 can exhibit intermittent elevations. In these cases, a 24-hour urine collection is preferred. For 24-hour urine collection, order TLTE4 / Leukotriene E4, 24 Hour, Urine.
Additional Testing Requirements
For an optimal evaluation, testing for urinary leukotriene E4 should be accompanied with laboratory investigations for the presence of serum tryptase (TRYPT / Tryptase, Serum), urinary 2,3-dinor 11 beta-prostaglandin F2 alpha (23BPR / 2,3-Dinor 11 Beta-Prostaglandin F2 Alpha, Random, Urine) and urinary N-methylhistamine (NMHR / N-Methylhistamine, Random, Urine).
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions:
1. Within a few hours of symptom onset, collect a random urine specimen.
2. No preservative
3. Aliquot urine into a plastic vial and send frozen.
Useful For
Aiding in the evaluation of patients at-risk for mast cell activation syndrome (eg, systemic mastocytosis, IgE-mediated allergies, or aspirin-exacerbated respiratory disease) using random urine collections
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| LTE4R | Leukotriene E4, Random, U | No | Yes |
| CRTFR | Creatinine, Random, U | No | Yes |
Method Name
LTE4R: Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
CRTFR: Enzymatic Colorimetric Assay
Reporting Name
Leukotriene E4, Random, USpecimen Type
UrineSpecimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 28 days | |
| Refrigerated | 7 days | ||
| Ambient | 24 hours |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
LEUKOTRIENE E4
≤104 pg/mg creatinine
CREATININE
≥18 years old: 16-326 mg/dL
Reference values have not been established for patients who are younger than 18 years of age.
Day(s) Performed
Monday, Tuesday, Thursday
Report Available
2 to 9 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82542
82570
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| RLTE4 | Leukotriene E4, Random, U | 33343-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 603457 | Leukotriene E4, Random, U | 33343-5 |
| CRTFR | Creatinine, Random, U | 2161-8 |