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Serotonin, Blood

Additional Codes

Primary ID

Epic Code Mayo Test ID

SEROTB

LAB2419 SERWB

 

Reporting Name

Serotonin, B

Useful For

In conjunction with, or as an alternative to first-order test in the differential diagnosis of isolated symptoms suggestive of carcinoid syndrome, in particular flushing (5-HIAA or serum chromogranin A measurements are first-line tests)

 

Second-order test in the follow-up of patients with known or treated carcinoid tumors in whole blood specimens

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Whole Blood EDTA


Additional Testing Requirements


First-line testing for the diagnosis of carcinoid tumors with symptoms suggestive of carcinoid syndrome consists of urinary serotonin (SERU / Serotonin, 24 Hour, Urine), urinary 5-HIAA (HIAA / 5-Hydroxyindoleacetic Acid [5-HIAA], 24 Hour, Urine), and serum chromogranin A (CGAK / Chromogranin A, Serum).



Specimen Required


Supplies: Serotonin Tube (T259)

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Serotonin tube (T259) containing ascorbic acid

Specimen Volume: 2.5 mL

Collection Instructions:

1. Immediately after the venipuncture, transfer approximately 2.5 mL of whole blood to serotonin tube and mix well (any volume of whole blood from 1.5-3 mL is acceptable).

2. Immediately freeze specimen (necessary to lyse the RBCs).


Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Frozen 90 days SEROTONIN TUBE

Reject Due To

Gross lipemia OK
Gross icterus OK

Reference Values

≤330 ng/mL

 

For SI unit Reference Values, see https://www.mayomedicallaboratories.com/order-tests/si-unit-conversion.html

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 10 a.m.

CPT Code Information

84260

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SERWB Serotonin, B 2939-7

 

Result ID Test Result Name Result LOINC Value
84373 Serotonin, B 2939-7

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Analytic Time

4 days

Specimen Retention Time

3 months

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.